OR52D1

Olfactory receptor 52D1 is a protein that in humans is encoded by the OR52D1 gene.^[5]

OR52D1
Identifiers
Aliases	OR52D1, OR11-43, olfactory receptor family 52 subfamily D member 1, olfactory receptor family 52 subfamily D member 1 (gene/pseudogene)
External IDs	MGI: 3030480; HomoloGene: 17481; GeneCards: OR52D1; OMA:OR52D1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 5,488,685 bp[1] End 5,489,749 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 103,754,080 bp[2] End 103,758,973 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Achilles tendon left testis skin of thigh right testis n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 390066 259058 Ensembl ENSG00000181609 ENSMUSG00000073931 UniProt Q9H346 Q8VGW2 RefSeq (mRNA) NM_001005163 NM_147056 RefSeq (protein) NP_001005163 NP_667267 Location (UCSC) Chr 11: 5.49 – 5.49 Mb Chr 7: 103.75 – 103.76 Mb PubMed search [3] [4]
Wikidata
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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[5]

Ligands

Compared to other olfactory receptors such as OR1G1, OR52D1 has a more narrow/specific range of ligands.^[6]

Agonists:

• Methyl octanoate^[6]
• "Better activated by acids, aldehydes, ketones and esters than alcohols or pyrazines"^[6]

See also

• Olfactory receptor