OR7D4

Olfactory receptor 7D4 is a protein that in humans is encoded by the OR7D4 gene.^{[5][6][7][8][9][10][11]}

OR7D4
Identifiers
Aliases	OR7D4, OR19-7, OR19-B, OR19B, OR7D4P, hg105, olfactory receptor family 7 subfamily D member 4
External IDs	OMIM: 611538; MGI: 1313142; HomoloGene: 81583; GeneCards: OR7D4; OMA:OR7D4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 9,210,276 bp[1] End 9,219,589 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A3|9 7.51 cM Start 20,193,647 bp[2] End 20,198,874 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence renal cortex Top expressed in proximal tubule More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity olfactory receptor activity Cellular component membrane plasma membrane integral component of membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 125958 258822 Ensembl ENSG00000174667 ENSMUSG00000059623 UniProt Q8NG98 n/a RefSeq (mRNA) NM_001005191 NM_146825 RefSeq (protein) NP_001005191 n/a Location (UCSC) Chr 19: 9.21 – 9.22 Mb Chr 9: 20.19 – 20.2 Mb PubMed search [3] [4]
Wikidata
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Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[5]

Ligands

• Androstadienone^[12]
• Androstenone^[13]

People with the OR7D4 R88W/T133M polymorphism are less sensitive to these odorants and find them less offensive smelling, as they are characteristically described as "sweaty".^[8]