ORM1

Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene.^[5]

ORM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KQ0
Identifiers
Aliases	ORM1, AGP-A, AGP1, HEL-S-153w, ORM, orosomucoid 1
External IDs	OMIM: 138600; MGI: 97445; HomoloGene: 128040; GeneCards: ORM1; OMA:ORM1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q32 Start 114,323,098 bp[1] End 114,326,479 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 B3|4 33.96 cM Start 63,274,399 bp[2] End 63,277,748 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver testicle bone marrow bone marrow cell blood trabecular bone granulocyte right lung right adrenal gland upper lobe of left lung Top expressed in seminal vesicula granulocyte embryo adrenal gland white adipose tissue liver brown adipose tissue tunica adventitia of aorta left lobe of liver neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component blood microparticle extracellular exosome platelet alpha granule lumen extracellular space specific granule lumen tertiary granule lumen extracellular matrix extracellular region collagen-containing extracellular matrix Biological process negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production regulation of immune system process inflammatory response acute-phase response platelet degranulation neutrophil degranulation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5004 18407 Ensembl ENSG00000229314 ENSMUSG00000028359 UniProt P02763 Q63805 RefSeq (mRNA) NM_000607 NM_013623 NM_001379520 NM_001379521 RefSeq (protein) NP_000598 n/a Location (UCSC) Chr 9: 114.32 – 114.33 Mb Chr 4: 63.27 – 63.28 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression.^[5]

Interactions

ORM1 has been shown to interact with Plasminogen activator inhibitor-1.^[6]

See also

• Orosomucoid