OS9 (gene)

Protein OS-9 is a protein that in humans is encoded by the OS9 gene.^{[5][6][7][8][9]}

OS9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3AIH
Identifiers
Aliases	OS9, ERLEC2, OS-9, endoplasmic reticulum lectin, OS9 endoplasmic reticulum lectin
External IDs	OMIM: 609677; MGI: 1924301; HomoloGene: 31409; GeneCards: OS9; OMA:OS9 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3-q14.1 Start 57,693,955 bp[1] End 57,721,557 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 126,931,519 bp[2] End 126,957,000 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon tendon of biceps brachii stromal cell of endometrium monocyte granulocyte body of pancreas islet of Langerhans minor salivary glands right lobe of thyroid gland mucosa of ileum Top expressed in lacrimal gland neural layer of retina submandibular gland granulocyte right kidney lip dentate gyrus of hippocampal formation granule cell parotid gland superior frontal gyrus molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carbohydrate binding protein binding protease binding Cellular component Hrd1p ubiquitin ligase complex endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum quality control compartment endoplasmic reticulum Biological process protein targeting protein retention in ER lumen negative regulation of retrograde protein transport, ER to cytosol protein ubiquitination ubiquitin-dependent ERAD pathway response to endoplasmic reticulum stress endoplasmic reticulum mannose trimming transmembrane transport ubiquitin-dependent protein catabolic process retrograde protein transport, ER to cytosol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10956 216440 Ensembl ENSG00000135506 ENSMUSG00000040462 UniProt Q13438 Q8K2C7 RefSeq (mRNA) NM_001017956 NM_001017957 NM_001017958 NM_001261420 NM_001261421 NM_001261422 NM_001261423 NM_006812 NM_001171026 NM_177614 RefSeq (protein) NP_001017956 NP_001017957 NP_001017958 NP_001248349 NP_001248350 NP_001248351 NP_001248352 NP_006803 NP_001164497 NP_808282 Location (UCSC) Chr 12: 57.69 – 57.72 Mb Chr 10: 126.93 – 126.96 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[9]