OSBP2

Oxysterol-binding protein 2 is a protein that in humans is encoded by the OSBP2 gene.^[5][6][7][8]

OSBP2
Identifiers
Aliases	OSBP2, HLM, ORP-4, ORP4, OSBPL1, OSBPL4, oxysterol binding protein 2
External IDs	OMIM: 606729; MGI: 1921559; HomoloGene: 75303; GeneCards: OSBP2; OMA:OSBP2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 30,693,782 bp[1] End 30,907,824 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 3,653,731 bp[2] End 3,813,903 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell left testis right testis monocyte right hemisphere of cerebellum blood prefrontal cortex right frontal lobe trabecular bone male germ cell Top expressed in spermatid neural layer of retina interventricular septum seminiferous tubule spermatocyte visual cortex primary visual cortex superior frontal gyrus retinal pigment epithelium lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cholesterol binding protein binding lipid binding sterol transporter activity sterol binding Cellular component membrane apical dendrite cytosol plasma membrane intracellular membrane-bounded organelle perinuclear endoplasmic reticulum Biological process lipid transport spermatid development sterol transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23762 74309 Ensembl ENSG00000184792 ENSMUSG00000020435 UniProt Q969R2 Q5QNQ6 RefSeq (mRNA) NM_001003812 NM_001282738 NM_001282739 NM_001282740 NM_001282741 NM_001282742 NM_030758 NM_152818 NM_001302630 NM_001302631 NM_001363163 NM_001363164 RefSeq (protein) NP_001269667 NP_001269668 NP_001269669 NP_001269670 NP_001269671 NP_110385 NP_001289559 NP_001289560 NP_690031 NP_001350092 NP_001350093 Location (UCSC) Chr 22: 30.69 – 30.91 Mb Chr 11: 3.65 – 3.81 Mb PubMed search [3] [4]
Wikidata
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Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized.^[8]