OSBPL3

Oxysterol-binding protein-related protein 3 is a protein that in humans is encoded by the OSBPL3 gene.^[5][6]

OSBPL3
Identifiers
Aliases	OSBPL3, ORP-3, ORP3, OSBP3, oxysterol binding protein like 3
External IDs	OMIM: 606732; MGI: 1918970; HomoloGene: 49422; GeneCards: OSBPL3; OMA:OSBPL3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p15.3 Start 24,796,540 bp[1] End 24,981,634 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B2.3 Start 50,270,310 bp[2] End 50,433,181 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell amniotic fluid oocyte secondary oocyte left lobe of thyroid gland gonad right lobe of thyroid gland stromal cell of endometrium mucosa of paranasal sinus skin of abdomen Top expressed in transitional epithelium of urinary bladder lumbar spinal ganglion epithelium of stomach proximal tubule right kidney human kidney otolith organ utricle ascending aorta adrenal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cholesterol binding protein binding lipid binding sterol transporter activity sterol binding Cellular component perinuclear endoplasmic reticulum cell projection cytoplasm endoplasmic reticulum membrane filopodium tip nuclear membrane endoplasmic reticulum plasma membrane nucleus membrane cytosol intracellular membrane-bounded organelle Biological process lipid transport bile acid biosynthetic process sterol transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26031 71720 Ensembl ENSG00000070882 ENSMUSG00000029822 UniProt Q9H4L5 Q9DBS9 RefSeq (mRNA) NM_015550 NM_145320 NM_145321 NM_145322 NM_145323 NM_145324 NM_001163645 NM_027881 NM_001347213 RefSeq (protein) NP_056365 NP_663160 NP_663161 NP_663162 NP_001157117 NP_001334142 NP_082157 Location (UCSC) Chr 7: 24.8 – 24.98 Mb Chr 6: 50.27 – 50.43 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Several transcript variants encoding different isoforms have been identified.^[6]