OTUB2

Ubiquitin thioesterase OTUB2 is an enzyme that in humans is encoded by the OTUB2 gene.^[5][6]

OTUB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TFF, 4FJV
Identifiers
Aliases	OTUB2, C14orf137, OTB2, OTU2, OTU deubiquitinase, ubiquitin aldehyde binding 2
External IDs	OMIM: 608338; MGI: 1915399; HomoloGene: 57056; GeneCards: OTUB2; OMA:OTUB2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.12 Start 94,026,340 bp[1] End 94,048,930 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 E Start 103,354,941 bp[2] End 103,372,609 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle left testis right testis skin of leg ventricular zone gonad skin of abdomen ganglionic eminence placenta islet of Langerhans Top expressed in seminiferous tubule spermatid esophagus primary oocyte lip dentate gyrus of hippocampal formation granule cell zygote Region I of hippocampus proper lacrimal gland secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function thiol-dependent deubiquitinase peptidase activity cysteine-type peptidase activity NEDD8-specific protease activity ubiquitin binding protein binding hydrolase activity Cellular component nucleus Biological process protein deubiquitination protein K63-linked deubiquitination protein K48-linked deubiquitination proteolysis protein K11-linked deubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 78990 68149 Ensembl ENSG00000089723 ENSG00000277276 ENSMUSG00000021203 UniProt Q96DC9 Q9CQX0 RefSeq (mRNA) NM_023112 NM_001177841 NM_026580 RefSeq (protein) NP_075601 NP_001171312 NP_080856 Location (UCSC) Chr 14: 94.03 – 94.05 Mb Chr 12: 103.35 – 103.37 Mb PubMed search [3] [4]
Wikidata
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Otubains are deubiquitinating cysteine proteases (DUBs; see MIM 602519) that belong to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin (UB; see MIM 191339)-protein bond.^[6]