OTUD7B

OTU domain-containing protein 7B is a protein that in humans is encoded by the OTUD7B gene.^[5][6]

OTUD7B
Identifiers
Aliases	OTUD7B, CEZANNE, ZA20D1, OTU deubiquitinase 7B
External IDs	OMIM: 611748; MGI: 2654703; HomoloGene: 10624; GeneCards: OTUD7B; OMA:OTUD7B - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.2 Start 149,937,812 bp[1] End 150,010,726 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 96,011,839 bp[2] End 96,068,446 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell internal globus pallidus sural nerve secondary oocyte tendon of biceps brachii corpus callosum inferior ganglion of vagus nerve C1 segment Skeletal muscle tissue of biceps brachii epithelium of colon Top expressed in blood retinal pigment epithelium sciatic nerve right lung lobe neural layer of retina spermatid lumbar subsegment of spinal cord spermatocyte triceps brachii muscle muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding cysteine-type peptidase activity zinc ion binding metal ion binding peptidase activity K63-linked polyubiquitin modification-dependent protein binding protein binding thiol-dependent deubiquitinase hydrolase activity Lys48-specific deubiquitinase activity Cellular component cytoplasm nucleus cytosol Biological process mucosal immune response negative regulation of protein localization to nucleus protein K48-linked deubiquitination protein deubiquitination involved in ubiquitin-dependent protein catabolic process immune system process negative regulation of transcription by RNA polymerase II negative regulation of I-kappaB kinase/NF-kappaB signaling proteolysis negative regulation of interleukin-8 production protein K63-linked deubiquitination immune response protein deubiquitination protein K11-linked deubiquitination adaptive immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56957 229603 Ensembl ENSG00000264522 ENSMUSG00000038495 UniProt Q6GQQ9 B2RUR8 RefSeq (mRNA) NM_020205 NM_001025613 NM_001025614 RefSeq (protein) NP_064590 NP_001020784 NP_001020785 Location (UCSC) Chr 1: 149.94 – 150.01 Mb Chr 3: 96.01 – 96.07 Mb PubMed search [3] [4]
Wikidata
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