OXR1

Oxidation resistance protein 1 is a protein that in humans is encoded by the OXR1 gene.^[5][6] Loss of OXR1 function causes decline of the retromer complex.^[7]

OXR1
Identifiers
Aliases	OXR1, TLDC3, Nbla00307, oxidation resistance 1, CHEGDD
External IDs	OMIM: 605609; MGI: 2179326; HomoloGene: 24993; GeneCards: OXR1; OMA:OXR1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q23.1 Start 106,270,144 bp[1] End 106,752,694 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B3.1 Start 41,310,878 bp[2] End 41,724,444 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons Achilles tendon lateral nuclear group of thalamus trigeminal ganglion sperm spinal ganglia seminal vesicula Brodmann area 23 corpus epididymis prefrontal cortex Top expressed in medial dorsal nucleus parotid gland subiculum pontine nuclei primary motor cortex habenula medial geniculate nucleus lobe of cerebellum cerebellar vermis inferior colliculi More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity protein binding molecular function Cellular component nucleolus mitochondrion cellular component nucleoplasm intracellular membrane-bounded organelle Biological process negative regulation of neuron apoptotic process response to oxidative stress cellular response to hydroperoxide adult walking behavior neuron apoptotic process negative regulation of cellular response to oxidative stress negative regulation of peptidyl-cysteine S-nitrosylation negative regulation of oxidative stress-induced neuron death Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55074 170719 Ensembl ENSG00000164830 ENSMUSG00000022307 UniProt Q8N573 Q4KMM3 RefSeq (mRNA) NM_001198532 NM_001198533 NM_001198534 NM_001198535 NM_018002 NM_181354 NM_001130163 NM_001130164 NM_001130165 NM_001130166 NM_130885 NM_001358976 NM_001358977 NM_001358978 RefSeq (protein) NP_001185461 NP_001185462 NP_001185463 NP_001185464 NP_060472 NP_851999 NP_001123635 NP_001123636 NP_001123637 NP_001123638 NP_570955 NP_001345905 NP_001345906 NP_001345907 Location (UCSC) Chr 8: 106.27 – 106.75 Mb Chr 15: 41.31 – 41.72 Mb PubMed search [3] [4]
Wikidata
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