PA2G4

Proliferation-associated protein 2G4 (PA2G4) also known as ErbB3-binding protein 1 (EBP1) is a protein that in humans is encoded by the PA2G4 gene.^[5]

PA2G4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Q8K, 3J2I
Identifiers
Aliases	PA2G4, EBP1, HG4-1, p38-2G4, proliferation-associated 2G4
External IDs	OMIM: 602145; MGI: 894684; HomoloGene: 4513; GeneCards: PA2G4; OMA:PA2G4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.2 Start 56,104,537 bp[1] End 56,113,910 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 128,393,635 bp[2] End 128,401,856 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen mucosa of esophagus rectum ganglionic eminence islet of Langerhans ventricular zone tendon of biceps brachii gastrocnemius muscle body of pancreas Top expressed in tail of embryo epiblast morula genital tubercle somite embryo blastocyst embryo migratory enteric neural crest cell abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity protein binding ubiquitin protein ligase binding RNA binding nucleic acid binding Cellular component cytoplasm membrane nucleolus extracellular exosome nucleus extracellular region azurophil granule lumen Biological process regulation of transcription, DNA-templated transcription, DNA-templated rRNA processing cell population proliferation negative regulation of transcription, DNA-templated regulation of translation neutrophil degranulation negative regulation of apoptotic process positive regulation of cell differentiation ribosomal large subunit export from nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5036 18813 Ensembl ENSG00000170515 ENSMUSG00000025364 UniProt Q9UQ80 P50580 RefSeq (mRNA) NM_006191 NM_011119 RefSeq (protein) NP_006182 NP_035249 Location (UCSC) Chr 12: 56.1 – 56.11 Mb Chr 10: 128.39 – 128.4 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional corepressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Paradoxically, the expression of EBP1 is decreased in prostate cancer,^[6] but increased in Acute Myelogneous Leukemia.^[7] Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified.^[8]

Interactions

PA2G4 has been shown to interact with ERBB3,^[9][10] retinoblastoma protein,^[11] and androgen receptor.^[12]