PACSIN1

Protein kinase C and casein kinase substrate in neurons protein 1 also known as syndapin I^[5][6] is an enzyme that in humans is encoded by the PACSIN1 gene.^[7]

PACSIN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HAH, 3HAI, 3Q84, 3QNI
Identifiers
Aliases	PACSIN1, SDPI, protein kinase C and casein kinase substrate in neurons 1
External IDs	OMIM: 606512; MGI: 1345181; HomoloGene: 22674; GeneCards: PACSIN1; OMA:PACSIN1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.31 Start 34,466,061 bp[1] End 34,535,229 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 27,874,483 bp[2] End 27,930,456 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe superior frontal gyrus postcentral gyrus entorhinal cortex middle temporal gyrus primary visual cortex dorsolateral prefrontal cortex anterior cingulate cortex right hemisphere of cerebellum prefrontal cortex Top expressed in pontine nuclei piriform cortex superior frontal gyrus primary visual cortex subiculum dorsal tegmental nucleus cerebellar cortex neural layer of retina primary motor cortex prefrontal cortex More reference expression data BioGPS n/a
Gene ontology Molecular function cytoskeletal protein binding protein binding phospholipid binding lipid binding identical protein binding Cellular component cytoplasm axon terminus cytosol endosome cell projection membrane myelin sheath plasma membrane synapse ruffle membrane cell junction perinuclear region of cytoplasm neuron projection cytoplasmic vesicle membrane cytoplasmic vesicle COPI-coated vesicle cytoskeleton photoreceptor ribbon synapse presynaptic endocytic zone Biological process regulation of endocytosis negative regulation of endocytosis protein localization to membrane neuron projection morphogenesis endocytosis actin filament organization neuron development positive regulation of dendrite development plasma membrane tubulation synaptic vesicle endocytosis protein localization to plasma membrane cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29993 23969 Ensembl ENSG00000124507 ENSMUSG00000040276 UniProt Q9BY11 Q61644 RefSeq (mRNA) NM_001199583 NM_020804 NM_001286743 NM_001286744 NM_011861 NM_178365 RefSeq (protein) NP_001186512 NP_065855 NP_001273672 NP_001273673 NP_035991 NP_848142 Location (UCSC) Chr 6: 34.47 – 34.54 Mb Chr 17: 27.87 – 27.93 Mb PubMed search [3] [4]
Wikidata
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Interactions

PACSIN1 has been shown to interact with GTPases of the Dynamin family (Dynamin 1, 2 and 3). Based on this interaction, its localization and functional role the protein was named syndapin I (synaptic dynamin-associated protein I).

A variety of interactions have been published:

• DNM1^[8][9][10]
• Huntingtin^[11]
• PACSIN2^[10][12]
• PACSIN3^[10]