PADI1

Peptidyl arginine deiminase, type I, also known as PADI1, is a protein which in humans is encoded by the PADI1 gene.^[5][6]

PADI1
Identifiers
Aliases	PADI1, HPAD10, PAD1, PDI, PDI1, peptidyl arginine deiminase 1
External IDs	OMIM: 607934; MGI: 1338893; HomoloGene: 7881; GeneCards: PADI1; OMA:PADI1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.13 Start 17,205,128 bp[1] End 17,246,007 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D3|4 72.62 cM Start 140,540,294 bp[2] End 140,573,089 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vagina skin of leg skin of abdomen olfactory zone of nasal mucosa placenta tonsil substantia nigra minor salivary glands mucosa of transverse colon rectum Top expressed in cervix lip esophagus hair follicle conjunctival fornix decidua morula skin of back transitional epithelium of urinary bladder trachea More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding hydrolase activity protein-arginine deiminase activity metal ion binding Cellular component nucleus nucleoplasm cytoplasm cytosol Biological process chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29943 18599 Ensembl ENSG00000142623 ENSG00000281459 ENSMUSG00000025329 UniProt Q9ULC6 Q9Z185 RefSeq (mRNA) NM_013358 NM_011059 RefSeq (protein) NP_037490 NP_035189 Location (UCSC) Chr 1: 17.21 – 17.25 Mb Chr 4: 140.54 – 140.57 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes.^[5]