PAFAH1B2

Platelet-activating factor acetylhydrolase IB subunit beta is an enzyme that in humans is encoded by the PAFAH1B2 gene.^[5][6][7]

PAFAH1B2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1VYH
Identifiers
Aliases	PAFAH1B2, HEL-S-303, platelet activating factor acetylhydrolase 1b catalytic subunit 2
External IDs	OMIM: 602508; MGI: 108415; HomoloGene: 1932; GeneCards: PAFAH1B2; OMA:PAFAH1B2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 117,144,284 bp[1] End 117,176,894 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.2 Start 45,962,859 bp[2] End 46,012,690 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte pons inferior ganglion of vagus nerve superior vestibular nucleus trigeminal ganglion pars reticulata subthalamic nucleus pars compacta middle temporal gyrus lateral nuclear group of thalamus Top expressed in spermatid spermatocyte tail of embryo renal corpuscle genital tubercle mandibular prominence neural tube central gray substance of midbrain somite maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 1-alkyl-2-acetylglycerophosphocholine esterase activity platelet-activating factor acetyltransferase activity hydrolase activity protein homodimerization activity protein heterodimerization activity phospholipase A2 activity protein binding Cellular component plasma membrane nucleolus extracellular exosome fibrillar center extracellular region cytoplasm cytosol secretory granule lumen ficolin-1-rich granule lumen Biological process lipid catabolic process positive regulation of macroautophagy brain development spermatogenesis lipid metabolism neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5049 18475 Ensembl ENSG00000168092 ENSMUSG00000003131 UniProt P68402 Q61206 RefSeq (mRNA) NM_001184746 NM_001184747 NM_001184748 NM_001309431 NM_002572 NM_008775 RefSeq (protein) NP_001171675 NP_001171676 NP_001171677 NP_001296360 NP_002563 NP_032801 NP_001344167 NP_001344168 NP_001344169 NP_001344170 NP_001344172 NP_001344173 NP_001344174 NP_001344175 Location (UCSC) Chr 11: 117.14 – 117.18 Mb Chr 9: 45.96 – 46.01 Mb PubMed search [3] [4]
Wikidata
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Interactions

PAFAH1B2 has been shown to interact with PAFAH1B1.^[8]

See also

• PAFAH1B1
• PAFAH1B3