PAOX

Peroxisomal N(1)-acetyl-spermine/spermidine oxidase is an enzyme that in humans is encoded by the PAOX gene.^[5][6]

PAOX
Identifiers
Aliases	PAOX, PAO, polyamine oxidase (exo-N4-amino), polyamine oxidase
External IDs	OMIM: 615853; MGI: 1916983; HomoloGene: 72096; GeneCards: PAOX; OMA:PAOX - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.3 Start 133,379,261 bp[1] End 133,391,694 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F4 Start 139,695,712 bp[2] End 139,717,137 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis testicle gonad right lobe of liver mucosa of transverse colon spleen granulocyte sural nerve Top expressed in liver primary oocyte duodenum lip white adipose tissue epiblast esophagus zygote zone of skin bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function polyamine oxidase activity N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity spermine:oxygen oxidoreductase (spermidine-forming) activity N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity oxidoreductase activity signaling receptor binding Cellular component cytoplasm peroxisome peroxisomal matrix cytosol Biological process spermine metabolic process spermine catabolic process spermidine catabolic process positive regulation of spermidine biosynthetic process polyamine biosynthetic process putrescine biosynthetic process polyamine catabolic process putrescine catabolic process protein targeting to peroxisome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 196743 212503 Ensembl ENSG00000148832 ENSMUSG00000025464 UniProt Q6QHF9 Q8C0L6 RefSeq (mRNA) NM_152911 NM_207125 NM_207126 NM_207127 NM_207128 NM_207129 NM_153783 NM_001346725 RefSeq (protein) NP_690875 NP_997010 NP_997011 NP_001333654 NP_722478 Location (UCSC) Chr 10: 133.38 – 133.39 Mb Chr 7: 139.7 – 139.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse