PAPSS2

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 is an enzyme that in humans is encoded by the PAPSS2 gene.^[5][6]

PAPSS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AX4
Identifiers
Aliases	PAPSS2, ATPSK2, BCYM4, SK2, 3'-phosphoadenosine 5'-phosphosulfate synthase 2
External IDs	OMIM: 603005; MGI: 1330223; HomoloGene: 55840; GeneCards: PAPSS2; OMA:PAPSS2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.2-q23.31 Start 87,659,613 bp[1] End 87,747,705 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C1|19 27.46 cM Start 32,573,190 bp[2] End 32,644,587 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia mucosa of sigmoid colon lower lobe of lung cartilage tissue beta cell visceral pleura adrenal cortex right adrenal gland right adrenal cortex jejunal mucosa Top expressed in duodenum lacrimal gland pyloric antrum occiput occipital bone epithelium of stomach islet of Langerhans mucous cell of stomach finger lateral part of occipital bone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATP binding nucleotidyltransferase activity kinase activity catalytic activity nucleotide binding transferase activity sulfate adenylyltransferase (ATP) activity adenylylsulfate kinase activity Cellular component cytosol Biological process blood coagulation skeletal system development bone development phosphorylation metabolism sulfate assimilation 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9060 23972 Ensembl ENSG00000198682 ENSMUSG00000024899 UniProt O95340 Q5TB52 O88428 RefSeq (mRNA) NM_004670 NM_001015880 NM_001201470 NM_011864 NM_001360403 RefSeq (protein) NP_001015880 NP_004661 NP_004661.2 NP_001188399 NP_035994 NP_001347332 Location (UCSC) Chr 10: 87.66 – 87.75 Mb Chr 19: 32.57 – 32.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene.^[6]