PARG

For the Armenian singer, see Parg (musician).

Poly (ADP-ribose) glycohydrolase is an enzyme that in humans is encoded by the PARG gene.^[5][6][7]

PARG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4B1J, 5A7R, 4A0D, 4B1I, 4B1H, 4B1G
Identifiers
Aliases	PARG, PARG99, poly(ADP-ribose) glycohydrolase
External IDs	OMIM: 603501; MGI: 1347094; HomoloGene: 50532; GeneCards: PARG; OMA:PARG - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q11.23 Start 49,818,279 bp[1] End 49,970,203 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 B Start 31,923,906 bp[2] End 32,019,507 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon germinal epithelium testicle kidney tubule ventricular zone epithelium of nasopharynx ganglionic eminence corpus callosum gingival epithelium Skeletal muscle tissue of biceps brachii Top expressed in Gonadal ridge primitive streak stria vascularis pineal gland epiblast ureter morula tail of embryo morula abdominal wall More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity poly(ADP-ribose) glycohydrolase activity protein binding Cellular component mitochondrial matrix intracellular membrane-bounded organelle mitochondrion nucleus nucleoplasm cytoplasm cytosol Biological process ATP generation from poly-ADP-D-ribose carbohydrate metabolic process regulation of DNA repair nucleotide-sugar metabolic process cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8505 26430 Ensembl ENSG00000227345 ENSMUSG00000021911 UniProt Q86W56 O88622 RefSeq (mRNA) NM_001303486 NM_001303487 NM_001303489 NM_003631 NM_001324381 NM_011960 NM_001359915 NM_001374221 RefSeq (protein) NP_001290415 NP_001290416 NP_001290418 NP_001311310 NP_003622 NP_036090 NP_001346844 NP_001361150 Location (UCSC) Chr 10: 49.82 – 49.97 Mb Chr 14: 31.92 – 32.02 Mb PubMed search [3] [4]
Wikidata
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Poly (ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly (ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.^[5]