PARP2

Poly [ADP-ribose] polymerase 2 is an enzyme that in humans is encoded by the PARP2 gene.^[5][6][7] It is one of the PARP family of enzymes.

PARP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KCZ, 3KJD, 4PJV, 4TVJ, 4ZZX, 4ZZY, 5DSY, 5D5K
Identifiers
Aliases	PARP2, ADPRT2, ADPRTL2, ADPRTL3, ARTD2, PARP-2, pADPRT-2, poly(ADP-ribose) polymerase 2
External IDs	OMIM: 607725; MGI: 1341112; HomoloGene: 4004; GeneCards: PARP2; OMA:PARP2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 20,343,615 bp[1] End 20,357,904 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 26.25 cM|14 C1 Start 51,045,298 bp[2] End 51,058,758 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum right frontal lobe Brodmann area 9 gonad ventricular zone ganglionic eminence prefrontal cortex cerebellar vermis left ovary Top expressed in tail of embryo Ileal epithelium genital tubercle neural layer of retina otic placode epiblast ventricular zone embryo primitive streak embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity DNA binding protein binding DNA ligase (ATP) activity glycosyltransferase activity NAD+ ADP-ribosyltransferase activity protein ADP-ribosylase activity NAD DNA ADP-ribosyltransferase activity Cellular component cytoplasm nucleolus nucleus nucleoplasm Biological process DNA ligation involved in DNA repair lagging strand elongation protein ADP-ribosylation DNA repair extrinsic apoptotic signaling pathway base-excision repair peptidyl-serine ADP-ribosylation positive regulation of cell growth involved in cardiac muscle cell development negative regulation of neuron death double-strand break repair protein poly-ADP-ribosylation DNA ADP-ribosylation cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10038 11546 Ensembl ENSG00000129484 ENSMUSG00000036023 UniProt Q9UGN5 O88554 RefSeq (mRNA) NM_001042618 NM_005484 NM_009632 RefSeq (protein) NP_001036083 NP_005475 NP_033762 Location (UCSC) Chr 14: 20.34 – 20.36 Mb Chr 14: 51.05 – 51.06 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.^[7]

In the plant species Arabidopsis thaliana, PARP2 plays more significant roles than PARP1 in protective responses to DNA damage and bacterial pathogenesis.^[8] The plant PARP2 carries N-terminal SAP DNA binding motifs rather than the Zn-finger DNA binding motifs of plant and animal PARP1 proteins.^[8]

PARP inhibitor drugs

Some PARP inhibitor anti-cancer drugs (primarily aimed at PARP1) also inhibit PARP2, e.g. niraparib.

Interactions

PARP2 has been shown to interact with XRCC1.^[9]

PARP2 also interacts with HPF1.^[10][11][12]

PARP2 binds to and bridges blunt DNA ends.^[12][13][14]