PARP3

Poly [ADP-ribose] polymerase 3 is an enzyme that in humans is encoded by the PARP3 gene.^[5][6]

PARP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EOC, 3C49, 3C4H, 3CE0, 3FHB, 4GV0, 4GV2, 4GV4, 4L6Z, 4L70, 4L7L, 4L7N, 4L7O, 4L7P, 4L7R, 4L7U
Identifiers
Aliases	PARP3, ADPRT3, ADPRTL2, ADPRTL3, ARTD3, IRT1, PADPRT-3, poly(ADP-ribose) polymerase family member 3
External IDs	OMIM: 607726; MGI: 1891258; HomoloGene: 4005; GeneCards: PARP3; OMA:PARP3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.2 Start 51,942,345 bp[1] End 51,948,867 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F1 Start 106,347,521 bp[2] End 106,354,148 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal gland left adrenal cortex right lobe of liver apex of heart right lobe of thyroid gland left lobe of thyroid gland muscle layer of sigmoid colon transverse colon stromal cell of endometrium Top expressed in extraocular muscle ankle temporal muscle triceps brachii muscle digastric muscle sternocleidomastoid muscle vastus lateralis muscle gastrocnemius muscle mesenteric lymph nodes medial head of gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity glycosyltransferase activity catalytic activity NAD+ ADP-ribosyltransferase activity DNA ligase (ATP) activity protein ADP-ribosylase activity protein binding NAD DNA ADP-ribosyltransferase activity Cellular component cytoplasm site of double-strand break centriole cytoskeleton nucleus microtubule organizing center nucleolus chromosome Biological process protein localization to site of double-strand break DNA ligation involved in DNA repair lagging strand elongation regulation of mitotic spindle organization positive regulation of DNA ligation telomere maintenance double-strand break repair protein ADP-ribosylation DNA repair negative regulation of telomerase RNA reverse transcriptase activity protein poly-ADP-ribosylation DNA ADP-ribosylation negative regulation of isotype switching protein auto-ADP-ribosylation protein mono-ADP-ribosylation positive regulation of double-strand break repair via nonhomologous end joining cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10039 235587 Ensembl ENSG00000041880 ENSMUSG00000023249 UniProt Q9Y6F1 Q3ULW8 RefSeq (mRNA) NM_001003931 NM_001003935 NM_005485 NM_001370239 NM_001370240 NM_145619 NM_001311150 RefSeq (protein) NP_001003931 NP_005476 NP_001357168 NP_001357169 NP_001298079 NP_663594 Location (UCSC) Chr 3: 51.94 – 51.95 Mb Chr 9: 106.35 – 106.35 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.^[6]