PAWR

For the airport in Alaska using the ICAO location indicator PAWR, see Whittier Airport.

PRKC apoptosis WT1 regulator protein, or Prostate apoptosis response-4, is a tumor-suppressor protein coded for in the human by the PAWR gene, that induces apoptosis in cancer cells, but not in normal cells.

PAWR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JK9
Identifiers
Aliases	PAWR, Pawr, 2310001G03Rik, PAR4, Par-4, pro-apoptotic WT1 regulator
External IDs	OMIM: 601936; MGI: 2149961; HomoloGene: 1940; GeneCards: PAWR; OMA:PAWR - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q21.2 Start 79,574,979 bp[1] End 79,690,964 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D1 Start 108,167,982 bp[2] End 108,250,101 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium saphenous vein body of uterus epithelium of colon right coronary artery sural nerve tail of epididymis left uterine tube myometrium parietal pleura Top expressed in cumulus cell tunica media of zone of aorta Paneth cell hair follicle medullary collecting duct renal corpuscle ascending aorta vestibular membrane of cochlear duct calvaria lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription corepressor activity leucine zipper domain binding protein binding enzyme binding actin binding Cellular component cytoplasm nucleus actin filament Biological process regulation of transcription, DNA-templated transcription, DNA-templated actin filament bundle assembly negative regulation of T cell receptor signaling pathway negative regulation of T cell proliferation positive regulation of amyloid precursor protein biosynthetic process apoptotic signaling pathway negative regulation of B cell proliferation apoptotic process negative regulation of gene expression negative regulation of transcription by RNA polymerase II positive regulation of cellular senescence positive regulation of gene expression negative regulation of fibroblast proliferation positive regulation of hydrogen peroxide-mediated programmed cell death positive regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5074 114774 Ensembl ENSG00000177425 ENSMUSG00000035873 UniProt Q96IZ0 Q925B0 RefSeq (mRNA) NM_002583 NM_001354732 NM_001354733 NM_054056 RefSeq (protein) NP_002574 NP_001341661 NP_001341662 NP_473397 Location (UCSC) Chr 12: 79.57 – 79.69 Mb Chr 10: 108.17 – 108.25 Mb PubMed search [3] [4]
Wikidata
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Function

The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells.^[5] The active domain of the Par-4 protein has been found to confer cancer resistance in transgenic mice without compromising normal viability or aging, and may have therapeutic significance.^[6]

Interactions

PAWR has been shown to interact with:

• Protein AATF,^[7]
• DAPK3,^[8]
• Protein kinase Mζ,^[9]
• SLC5A1,^[10]
• THAP1,^[11] and
• WT1.^[12]