PBX2

Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.^[5][6]

PBX2
Identifiers
Aliases	PBX2, G17, HOX12, PBX2MHC, PBX homeobox 2
External IDs	OMIM: 176311; MGI: 1341793; HomoloGene: 48115; GeneCards: PBX2; OMA:PBX2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 32,184,733 bp[1] End 32,190,202 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 34,810,240 bp[2] End 34,816,374 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland granulocyte right ovary spleen body of uterus pituitary gland left ovary anterior pituitary left uterine tube Top expressed in genital tubercle tail of embryo granulocyte mandibular prominence maxillary prominence somite saccule germ layer ectoderm otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding transcription factor binding chromatin binding protein binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus transcription regulator complex Biological process proximal/distal pattern formation regulation of transcription, DNA-templated embryonic limb morphogenesis transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5089 18515 Ensembl ENSG00000224952 ENSG00000237344 ENSG00000236353 ENSG00000232005 ENSG00000225987 ENSG00000206315 ENSG00000204304 ENSMUSG00000034673 UniProt P40425 O35984 RefSeq (mRNA) NM_002586 NM_017463 RefSeq (protein) NP_002577 NP_059491 Location (UCSC) Chr 6: 32.18 – 32.19 Mb Chr 17: 34.81 – 34.82 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.^[6]

Interactions

PBX2 has been shown to interact with HOXA9.^[7]