PCBP2

Poly(rC)-binding protein 2 is a protein that in humans is encoded by the PCBP2 gene.^[5]

PCBP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AXY, 2JZX, 2P2R, 2PQU, 2PY9
Identifiers
Aliases	PCBP2, HNRNPE2, HNRPE2, hnRNP-E2, poly(rC) binding protein 2
External IDs	OMIM: 601210; MGI: 108202; HomoloGene: 74536; GeneCards: PCBP2; OMA:PCBP2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 53,452,102 bp[1] End 53,481,162 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F3|15 57.61 cM Start 102,470,539 bp[2] End 102,500,061 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone stromal cell of endometrium left testis right testis left ovary right adrenal cortex left lobe of thyroid gland right lobe of thyroid gland right ovary Top expressed in neural layer of retina epiblast hand ventricular zone somite molar thymus abdominal wall tail of embryo endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding enzyme binding nucleic acid binding ubiquitin protein ligase binding protein binding RNA binding C-rich single-stranded DNA binding Cellular component extracellular exosome membrane focal adhesion nucleoplasm cytoplasm nucleus cytosol postsynaptic density Biological process mRNA splicing, via spliceosome negative regulation of defense response to virus proteasome-mediated ubiquitin-dependent protein catabolic process defense response to virus mRNA metabolic process negative regulation of type I interferon production immune system process innate immune response viral RNA genome replication IRES-dependent viral translational initiation RNA metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5094 18521 Ensembl ENSG00000197111 ENSMUSG00000056851 UniProt Q15366 Q61990 RefSeq (mRNA) NM_031989 NM_001098620 NM_001128911 NM_001128912 NM_001128913 NM_001128914 NM_005016 NM_001103165 NM_001103166 NM_001174073 NM_011042 RefSeq (protein) NP_001092090 NP_001122383 NP_001122384 NP_001122385 NP_001122386 NP_005007 NP_114366 NP_001096635 NP_001096636 NP_001167544 NP_035172 NP_001361700 Location (UCSC) Chr 12: 53.45 – 53.48 Mb Chr 15: 102.47 – 102.5 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure.

It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1 intronless gene which has similar functions. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. It also has two processed pseudogenes PCBP2P1 and PCBP2P2. There are presently two alternatively spliced transcript variants described for this gene.^[6]

In humans, the PCBP2 gene overlaps with TUC338, a transcribed ultra-conserved element implicated in Hepatocellular carcinoma.^[7]

Interactions

PCBP2 has been shown to interact with HNRPK,^[8] PTBP1, and HNRNPL.^[8]