PCBP4

Poly(rC)-binding protein 4 is a protein that in humans is encoded by the PCBP4 gene.^[5][6]

PCBP4
Identifiers
Aliases	PCBP4, CBP, LIP4, MCG10, poly(rC) binding protein 4
External IDs	OMIM: 608503; MGI: 1890471; HomoloGene: 56926; GeneCards: PCBP4; OMA:PCBP4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.2 Start 51,957,454 bp[1] End 51,974,016 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F1 Start 106,453,291 bp[2] End 106,464,012 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum C1 segment tibial nerve sural nerve right frontal lobe muscle of thigh gastrocnemius muscle ganglionic eminence apex of heart Amygdala Top expressed in neural layer of retina cerebellar cortex lobe of cerebellum ventricular zone cerebellar vermis retinal pigment epithelium medial ganglionic eminence epiblast somite abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleic acid binding mRNA 3'-UTR binding RNA binding Cellular component cytoplasm cytosol Biological process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest regulation of mRNA stability Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57060 59092 Ensembl ENSG00000090097 ENSMUSG00000023495 UniProt P57723 P57724 RefSeq (mRNA) NM_001174100 NM_020418 NM_033008 NM_033009 NM_033010 NM_021567 RefSeq (protein) NP_001167571 NP_065151 NP_127501 NP_127503 NP_001350814 NP_067542 Location (UCSC) Chr 3: 51.96 – 51.97 Mb Chr 9: 106.45 – 106.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the KH domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined.^[6]