PCDH10

Protocadherin-10 is a protein that in humans is encoded by the PCDH10 gene.^[5][6]

PCDH10
Identifiers
Aliases	PCDH10, OL-PCDH, PCDH19, protocadherin 10
External IDs	OMIM: 608286; MGI: 1338042; HomoloGene: 74967; GeneCards: PCDH10; OMA:PCDH10 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q28.3 Start 133,149,294 bp[1] End 133,208,606 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 B Start 45,332,833 bp[2] End 45,390,058 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell prefrontal cortex internal globus pallidus Brodmann area 46 caudate nucleus nucleus accumbens superior frontal gyrus Brodmann area 23 stromal cell of endometrium putamen Top expressed in substantia nigra olfactory tubercle lateral hypothalamus globus pallidus dorsomedial hypothalamic nucleus primary motor cortex superior frontal gyrus paraventricular nucleus of hypothalamus nucleus accumbens medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process homophilic cell adhesion via plasma membrane adhesion molecules cell adhesion cell-cell signaling nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57575 18526 Ensembl ENSG00000138650 ENSMUSG00000049100 UniProt Q9P2E7 n/a RefSeq (mRNA) NM_020815 NM_032961 NM_001098170 NM_001098171 NM_001098172 NM_011043 RefSeq (protein) NP_065866 NP_116586 n/a Location (UCSC) Chr 4: 133.15 – 133.21 Mb Chr 3: 45.33 – 45.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The mRNA encodes a cadherin-related neuronal receptor thought to play a role in the establishment and function of specific cell-cell connections in the brain. This family member contains 6 extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. Alternatively spliced transcripts encode isoforms with unique cytoplasmic domains.^[6]