PCDH12

Protocadherin-12 is a protein that in humans is encoded by the PCDH12 gene.^[5][6][7]

PCDH12
Identifiers
Aliases	PCDH12, VE-cadherin-2, VECAD2, protocadherin 12, DMJDS1
External IDs	OMIM: 605622; MGI: 1855700; HomoloGene: 9574; GeneCards: PCDH12; OMA:PCDH12 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 141,943,581 bp[1] End 141,969,741 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B3 Start 38,400,142 bp[2] End 38,417,455 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii placenta right lung apex of heart vena cava spleen upper lobe of lung upper lobe of left lung lateral nuclear group of thalamus cardia Top expressed in left lung lobe renal corpuscle decidua right lung lobe endothelial cell of lymphatic vessel dermis embryo spermatocyte digastric muscle body of femur More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding Cellular component integral component of membrane cell junction plasma membrane integral component of plasma membrane extracellular exosome membrane cell-cell junction extracellular region Biological process glycogen metabolic process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules labyrinthine layer development neuron recognition homophilic cell adhesion via plasma membrane adhesion molecules cell adhesion cell-cell signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51294 53601 Ensembl ENSG00000113555 ENSMUSG00000024440 UniProt Q9NPG4 O55134 RefSeq (mRNA) NM_016580 NM_017378 RefSeq (protein) NP_057664 NP_059074 Location (UCSC) Chr 5: 141.94 – 141.97 Mb Chr 18: 38.4 – 38.42 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no effect on cell migration or growth.^[7]