PCDH8

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

PCDH8

Protocadherin-8 is a protein that in humans is encoded by the PCDH8 gene.[5][6][7]

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PCDH8
Identifiers
AliasesPCDH8, ARCADLIN, PAPC, protocadherin 8
External IDsOMIM: 603580; MGI: 1306800; HomoloGene: 1943; GeneCards: PCDH8; OMA:PCDH8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032949
NM_002590

NM_001042726
NM_021543

RefSeq (protein)

NP_002581
NP_116567

NP_001036191
NP_067518

Location (UCSC)Chr 13: 52.84 – 52.85 MbChr 14: 80 – 80.01 Mb
PubMed search[3][4]
Wikidata
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This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails.[7]

References

Further reading

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