PCDHA2

Protocadherin alpha-2 is a protein that in humans is encoded by the PCDHA2 gene.^[5][6]

PCDHA2
Identifiers
Aliases	PCDHA2, PCDH-ALPHA2, protocadherin alpha 2
External IDs	OMIM: 606308; MGI: 2681880; HomoloGene: 135719; GeneCards: PCDHA2; OMA:PCDHA2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 140,794,852 bp[1] End 141,012,347 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B2- B3 Start 37,072,258 bp[2] End 37,320,710 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence right hemisphere of cerebellum stromal cell of endometrium prefrontal cortex islet of Langerhans ventricular zone pituitary gland anterior pituitary Brodmann area 9 anterior cingulate cortex Top expressed in spermatid spermatocyte testicle neural tube ganglionic eminence cerebellar cortex dentate gyrus of hippocampal formation granule cell hippocampus proper Mesencephalon primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane nucleus endoplasmic reticulum Biological process cell adhesion nervous system development homophilic cell adhesion via plasma membrane adhesion molecules cell-cell signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56146 353234 Ensembl ENSG00000204969 ENSMUSG00000104148 UniProt Q9Y5H9 n/a RefSeq (mRNA) NM_031496 NM_018905 NM_031495 NM_198117 RefSeq (protein) NP_061728 NP_113683 NP_113684 n/a Location (UCSC) Chr 5: 140.79 – 141.01 Mb Chr 18: 37.07 – 37.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain.

These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.^[6]