PCDHA4

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

PCDHA4

Protocadherin alpha-4 is a protein that in humans is encoded by the PCDHA4 gene.[5][6][7]

Quick Facts Available structures, PDB ...
PCDHA4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPCDHA4, CNR1, CNRN1, CRNR1, PCDH-ALPHA4, protocadherin alpha 4
External IDsOMIM: 606310; MGI: 1298406; HomoloGene: 130626; GeneCards: PCDHA4; OMA:PCDHA4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031500
NM_018907

NM_007766

RefSeq (protein)

NP_061730
NP_113688

NP_001167625

Location (UCSC)Chr 5: 140.81 – 141.01 MbChr 18: 37.09 – 37.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Close

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.[7]

References

Further reading

Loading related searches...

Wikiwand - on

Seamless Wikipedia browsing. On steroids.