PCDHA6

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

PCDHA6

Protocadherin alpha-6 is a protein that in humans is encoded by the PCDHA6 gene.[5][6][7]

Quick Facts Identifiers, Aliases ...
PCDHA6
Identifiers
AliasesPCDHA6, CNR2, CNRN2, CNRS2, CRNR2, PCDH-ALPHA6, protocadherin alpha 6
External IDsOMIM: 606312; MGI: 1298367; HomoloGene: 75098; GeneCards: PCDHA6; OMA:PCDHA6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031849
NM_018909
NM_031848

NM_007767

RefSeq (protein)

NP_061732
NP_114036
NP_114037

n/a

Location (UCSC)Chr 5: 140.83 – 141.01 MbChr 18: 37.1 – 37.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Close

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.[7]

References

Further reading

Loading related searches...

Wikiwand - on

Seamless Wikipedia browsing. On steroids.