PCDHB13

Protocadherin beta-13 is a protein that in humans is encoded by the PCDHB13 gene.^[3][4]

PCDHB13
Identifiers
Aliases	PCDHB13, PCDH-BETA13, protocadherin beta 13
External IDs	OMIM: 606339; HomoloGene: 128504; GeneCards: PCDHB13; OMA:PCDHB13 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 141,213,919 bp[1] End 141,218,979 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad buccal mucosa cell tendon testicle right ventricle decidua stromal cell of endometrium ganglionic eminence islet of Langerhans corpus epididymis n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding Cellular component plasma membrane membrane integral component of membrane integral component of plasma membrane photoreceptor connecting cilium synapse postsynaptic membrane photoreceptor disc membrane Biological process chemical synaptic transmission homophilic cell adhesion via plasma membrane adhesion molecules synapse assembly calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56123 n/a Ensembl ENSG00000187372 n/a UniProt Q9Y5F0 n/a RefSeq (mRNA) NM_018933 n/a RefSeq (protein) NP_061756 n/a Location (UCSC) Chr 5: 141.21 – 141.22 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.^[4]