PCDHB7

Protocadherin beta-7 is a protein that in humans is encoded by the PCDHB7 gene.^[5][6]

PCDHB7
Identifiers
Aliases	PCDHB7, PCDH-BETA7, protocadherin beta 7
External IDs	OMIM: 606333; MGI: 2136750; HomoloGene: 32429; GeneCards: PCDHB7; OMA:PCDHB7 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 141,172,644 bp[1] End 141,176,383 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B3 Start 37,606,593 bp[2] End 37,609,393 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in visceral pleura parietal pleura Descending thoracic aorta ganglionic eminence smooth muscle tissue ascending aorta popliteal artery tibial arteries lactiferous gland lactiferous duct Top expressed in Region I of hippocampus proper submandibular gland ciliary body gastrula sciatic nerve nucleus of stria terminalis iris olfactory tubercle globus pallidus medial dorsal nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process homophilic cell adhesion via plasma membrane adhesion molecules cell adhesion chemical synaptic transmission synapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56129 93886 Ensembl ENSG00000113212 ENSMUSG00000047033 UniProt Q9Y5E2 Q91Y04 RefSeq (mRNA) NM_018940 NM_053140 RefSeq (protein) NP_061763 NP_444370 Location (UCSC) Chr 5: 141.17 – 141.18 Mb Chr 18: 37.61 – 37.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. The transcript for this particular family member uses more than one polyadenylation site.^[6]