PCDHGA11

Protocadherin gamma-A11 is a protein that in humans is encoded by the PCDHGA11 gene.^[5][6]

PCDHGA11
Identifiers
Aliases	PCDHGA11, PCDH-GAMMA-A11, protocadherin gamma subfamily A, 11
External IDs	OMIM: 606298; MGI: 1935228; HomoloGene: 110934; GeneCards: PCDHGA11; OMA:PCDHGA11 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 141,421,047 bp[1] End 141,512,975 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B3 Start 37,888,784 bp[2] End 37,974,926 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle stromal cell of endometrium ventricular zone ganglionic eminence Achilles tendon sural nerve apex of heart left ventricle right coronary artery Descending thoracic aorta Top expressed in ganglionic eminence olfactory bulb hippocampus proper striatum of neuraxis Mesencephalon rhombencephalon neural tube Cerebellum dentate gyrus of hippocampal formation granule cell ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process homophilic cell adhesion via plasma membrane adhesion molecules cell adhesion cell-cell signaling nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56105 93723 Ensembl ENSG00000253873 ENSMUSG00000102742 UniProt Q9Y5H2 Q91XY8 RefSeq (mRNA) NM_032092 NM_018914 NM_032091 NM_033594 RefSeq (protein) NP_061737 NP_114480 NP_114481 NP_291072 Location (UCSC) Chr 5: 141.42 – 141.51 Mb Chr 18: 37.89 – 37.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome 5. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression.

The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region.

These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.^[6]