PCK1

Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an enzyme which in humans is encoded by the PCK1 gene.^[5][6]

PCK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KHB, 1KHE, 1KHF, 1KHG, 1M51, 1NHX, 2GMV
Identifiers
Aliases	PCK1, PEPCK-C, PEPEPCKC, phosphoenolpyruvate carboxykinase 1, PCKDC
External IDs	OMIM: 614168; MGI: 97501; HomoloGene: 1944; GeneCards: PCK1; OMA:PCK1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.31 Start 57,561,080 bp[1] End 57,568,121 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H3|2 95.79 cM Start 172,994,841 bp[2] End 173,001,066 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa right lobe of liver glomerulus metanephric glomerulus kidney tubule human kidney mucosa of colon renal medulla mucosa of sigmoid colon mucosa of ileum Top expressed in right kidney brown adipose tissue human kidney left lobe of liver white adipose tissue subcutaneous adipose tissue tunica adventitia of aorta intercostal muscle mammary gland mesenteric lymph nodes More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding manganese ion binding GDP binding phosphoenolpyruvate carboxykinase activity GTP binding metal ion binding carboxylic acid binding purine nucleotide binding lyase activity carboxy-lyase activity magnesium ion binding phosphoenolpyruvate carboxykinase (GTP) activity Cellular component cytoplasm cytosol extracellular exosome Biological process glucose homeostasis internal protein amino acid acetylation lipid metabolism response to activity positive regulation of transcription from RNA polymerase II promoter in response to acidic pH oxaloacetate metabolic process response to insulin glyceroneogenesis cellular response to potassium ion starvation cellular response to retinoic acid response to lipid cellular response to hypoxia cellular response to fructose stimulus response to interleukin-6 glucose metabolic process ageing response to methionine cellular response to interleukin-1 cellular response to glucagon stimulus cellular response to cAMP cellular response to insulin stimulus cellular response to tumor necrosis factor response to lipopolysaccharide gluconeogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5105 18534 Ensembl ENSG00000124253 ENSMUSG00000027513 UniProt P35558 Q9Z2V4 RefSeq (mRNA) NM_002591 NM_011044 RefSeq (protein) NP_002582 NP_035174 Location (UCSC) Chr 20: 57.56 – 57.57 Mb Chr 2: 172.99 – 173 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This enzyme is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. A mitochondrial isozyme of the encoded protein also has been characterized.^[5]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Glycolysis and Gluconeogenesis edit]]

Glycolysis and Gluconeogenesis edit

1. The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

See also

• PEPCK