PCMT1

Protein-L-isoaspartate(D-aspartate) O-methyltransferase is an enzyme that in humans is encoded by the PCMT1 gene.^[5][6][7]

PCMT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1I1N, 1KR5
Identifiers
Aliases	PCMT1, PIMT, protein-L-isoaspartate (D-aspartate) O-methyltransferase
External IDs	OMIM: 176851; MGI: 97502; HomoloGene: 55895; GeneCards: PCMT1; OMA:PCMT1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.1 Start 149,749,443 bp[1] End 149,811,420 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 A1|10 2.26 cM Start 7,629,373 bp[2] End 7,681,136 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus Pons frontal pole spinal ganglia prefrontal cortex orbitofrontal cortex trigeminal ganglion superior vestibular nucleus Top expressed in spermatocyte Hypothalamus testicle lens quadriceps femoris muscle primary visual cortex superior frontal gyrus neural tube hippocampus proper cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity protein binding protein-L-isoaspartate (D-aspartate) O-methyltransferase activity cadherin binding Cellular component extracellular vesicle extracellular exosome cytoplasm cytosol Biological process methylation protein repair protein methylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5110 18537 Ensembl ENSG00000120265 ENSMUSG00000019795 UniProt P22061 P23506 RefSeq (mRNA) NM_001252049 NM_001252050 NM_001252051 NM_001252052 NM_001252053 NM_005389 NM_001360452 NM_001360456 NM_008786 NM_001347228 NM_001358647 NM_001358649 NM_001358651 NM_001358652 NM_001358653 NM_001358654 NM_001358657 RefSeq (protein) NP_001238978 NP_001238979 NP_001238980 NP_001238981 NP_001238982 NP_005380 NP_001347381 NP_001347385 n/a Location (UCSC) Chr 6: 149.75 – 149.81 Mb Chr 10: 7.63 – 7.68 Mb PubMed search [3] [4]
Wikidata
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Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 2.1.1.77) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.[supplied by OMIM]^[7]