PCSK4

Proprotein convertase subtilisin/kexin type 4 is an enzyme that in humans is encoded by the PCSK4 gene.^[5][6]

PCSK4
Identifiers
Aliases	PCSK4, PC4, SPC5, proprotein convertase subtilisin/kexin type 4
External IDs	OMIM: 600487; MGI: 97514; HomoloGene: 22495; GeneCards: PCSK4; OMA:PCSK4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 1,481,428 bp[1] End 1,490,752 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 80,321,283 bp[2] End 80,329,498 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis right uterine tube testicle anterior pituitary right lobe of liver right frontal lobe right lobe of thyroid gland left lobe of thyroid gland olfactory zone of nasal mucosa Top expressed in spermatid spermatocyte seminiferous tubule internal carotid artery external carotid artery neural layer of retina outer nuclear layer embryo proximal tubule embryo More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity serine-type peptidase activity hydrolase activity protein binding serine-type endopeptidase activity Cellular component integral component of membrane membrane acrosomal membrane cytoplasmic vesicle acrosomal vesicle trans-Golgi network integral component of Golgi membrane Biological process proteolysis binding of sperm to zona pellucida sperm capacitation acrosome reaction fertilization reproductive process protein processing peptide hormone processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54760 18551 Ensembl ENSG00000115257 ENSMUSG00000020131 UniProt Q6UW60 P29121 RefSeq (mRNA) NM_017573 NM_001395257 NM_008793 RefSeq (protein) NP_060043 NP_032819 Location (UCSC) Chr 19: 1.48 – 1.49 Mb Chr 10: 80.32 – 80.33 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse