PDCD4

Programmed cell death protein 4 is a protein that in humans is encoded by the PDCD4 gene.^[5][6] It is one of the targets of an oncomiR, MIRN21.^[7]

PDCD4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KZT, 2GGF, 2RG8, 2ZU6, 3EIJ
Identifiers
Aliases	PDCD4, H731, programmed cell death 4 (neoplastic transformation inhibitor), programmed cell death 4
External IDs	OMIM: 608610; MGI: 107490; HomoloGene: 7879; GeneCards: PDCD4; OMA:PDCD4 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q25.2 Start 110,871,795 bp[1] End 110,900,006 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 D2|19 48.73 cM Start 53,880,662 bp[2] End 53,918,291 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas skin of abdomen skin of leg rectum right lobe of thyroid gland left lobe of thyroid gland minor salivary glands left ovary ventricular zone right ovary Top expressed in lacrimal gland submandibular gland parotid gland lobe of prostate pyloric antrum aortic valve ascending aorta Ileal epithelium pineal gland corneal stroma More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component cytoplasm nucleus cytosol nucleoplasm Biological process regulation of protein metabolic process negative regulation of cell cycle negative regulation of apoptotic process negative regulation of transcription, DNA-templated negative regulation of JUN kinase activity positive regulation of smooth muscle cell apoptotic process negative regulation of myofibroblast differentiation apoptotic process positive regulation of endothelial cell apoptotic process BMP signaling pathway epithelial to mesenchymal transition involved in cardiac fibroblast development negative regulation of vascular associated smooth muscle cell differentiation positive regulation of inflammatory response cellular response to lipopolysaccharide negative regulation of cytokine production involved in inflammatory response positive regulation of NIK/NF-kappaB signaling interleukin-12-mediated signaling pathway negative regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27250 18569 Ensembl ENSG00000150593 ENSMUSG00000024975 UniProt Q53EL6 Q61823 RefSeq (mRNA) NM_145341 NM_001199492 NM_014456 NM_001168491 NM_001168492 NM_011050 RefSeq (protein) NP_001186421 NP_055271 NP_663314 NP_001161963 NP_001161964 NP_035180 Location (UCSC) Chr 10: 110.87 – 110.9 Mb Chr 19: 53.88 – 53.92 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.^[6]

Interactions

PDCD4 has been shown to interact with RPS13,^[8] ribosomal protein L5,^[8] p62, LC3 and Ubiquitin [9]