PDCD5

Programmed cell death protein 5 is a protein, originally identified as an apoptosis-accelerating protein,^[4] that in humans is encoded by the PDCD5 gene.^[5][6]

PDCD5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YYB, 2CRU, 2K6B
Identifiers
Aliases	PDCD5, TFAR19, programmed cell death 5
External IDs	OMIM: 604583; MGI: 3782009; HomoloGene: 10506; GeneCards: PDCD5; OMA:PDCD5 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.11 Start 32,581,190 bp[1] End 32,587,453 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis body of pancreas anterior pituitary right auricle of heart left coronary artery muscle layer of sigmoid colon gastric mucosa apex of heart anterior cingulate cortex n/a More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding heparin binding protein binding acetyltransferase activator activity beta-tubulin binding Cellular component cytoplasm extracellular exosome nucleus cytosol Biological process cellular response to transforming growth factor beta stimulus negative regulation of chaperone-mediated protein folding positive regulation of release of cytochrome c from mitochondria apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of gene expression positive regulation of protein insertion into mitochondrial outer membrane negative regulation of cell population proliferation positive regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9141 100042424 Ensembl ENSG00000105185 n/a UniProt O14737 P56812 RefSeq (mRNA) NM_004708 XM_001478256 RefSeq (protein) NP_004699 NP_062720 Location (UCSC) Chr 19: 32.58 – 32.59 Mb n/a PubMed search [2] [3]
Wikidata
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This gene encodes a protein expressed in tumor cells during apoptosis independent of the apoptosis-inducing stimuli. Prior to apoptosis induction, this gene product is distributed in both the nucleus and cytoplasm.

Once apoptosis is induced, the level of this protein increases and by relocation from the cytoplasm, it accumulates in the nucleus. Although its exact function is not defined, this protein is thought to play an early and universal role in apoptosis.^[6]