Phosducin-like

Phosducin-like protein is a protein that in humans is encoded by the PDCL gene.^[5][6]

PDCL
Identifiers
Aliases	PDCL, PhLP, Phosducin-like, phosducin like
External IDs	OMIM: 604421; MGI: 1914716; HomoloGene: 38043; GeneCards: PDCL; OMA:PDCL - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.2 Start 122,798,389 bp[1] End 122,828,588 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 37,240,086 bp[2] End 37,249,344 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell endothelial cell visceral pleura oocyte parietal pleura tibia Achilles tendon secondary oocyte germinal epithelium epithelium of nasopharynx Top expressed in pineal gland cumulus cell neural layer of retina medial ganglionic eminence stria vascularis carotid body superior cervical ganglion vestibular sensory epithelium mandibular prominence maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding queuine tRNA-ribosyltransferase activity protein-containing complex binding Cellular component cytoplasm cytosol cilium cell projection Biological process queuosine biosynthetic process heterotrimeric G-protein complex assembly regulation of G protein-coupled receptor signaling pathway negative regulation of protein refolding signal transduction visual perception response to stimulus protein folding positive regulation of smoothened signaling pathway cell projection organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5082 67466 Ensembl ENSG00000136940 ENSMUSG00000009030 UniProt Q13371 Q9DBX2 RefSeq (mRNA) NM_005388 NM_026176 RefSeq (protein) NP_005379 NP_080452 Location (UCSC) Chr 9: 122.8 – 122.83 Mb Chr 2: 37.24 – 37.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in the retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins.^[6]