PDE11A

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene.^[4][5]

PDE11A
Identifiers
Aliases	PDE11A, PPNAD2, phosphodiesterase 11A
External IDs	OMIM: 604961; MGI: 3036251; HomoloGene: 56763; GeneCards: PDE11A; OMA:PDE11A - orthologs
Gene location (Mouse) Chr. Chromosome 2 (mouse)[1] Band 2|2 C3 Start 75,819,485 bp[1] End 76,169,118 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in deltoid muscle quadriceps femoris muscle vastus lateralis muscle liver gastrocnemius muscle prostate biceps brachii right lobe of liver tibialis anterior muscle tibia Top expressed in hippocampus proper dentate gyrus of hippocampal formation granule cell embryo ileum primary visual cortex midbrain tegmentum jejunum Cortex of frontal lobe white adipose tissue cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoric diester hydrolase activity catalytic activity 3',5'-cyclic-nucleotide phosphodiesterase activity hydrolase activity metal ion binding cGMP-stimulated cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-GMP phosphodiesterase activity cyclic-nucleotide phosphodiesterase activity cGMP binding Cellular component cytoplasm cytosol cellular component Biological process metabolism signal transduction G protein-coupled receptor signaling pathway negative regulation of cGMP-mediated signaling negative regulation of cAMP-mediated signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50940 241489 Ensembl n/a ENSMUSG00000075270 UniProt Q9HCR9 P0C1Q2 RefSeq (mRNA) NM_016953 NM_001077196 NM_001077197 NM_001077358 NM_001081033 RefSeq (protein) NP_001070664 NP_001070665 NP_001070826 NP_058649 NP_001074502 Location (UCSC) n/a Chr 2: 75.82 – 76.17 Mb PubMed search [2] [3]
Wikidata
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The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing's disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.^[5]

Inhibitors

• BC11-38 ^[6]