PDE4C

cAMP-specific 3',5'-cyclic phosphodiesterase 4C is an enzyme that in humans is encoded by the PDE4C gene.^[5]

PDE4C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QYM
Identifiers
Aliases	PDE4C, DPDE1, phosphodiesterase 4C, PDE21
External IDs	OMIM: 600128; MGI: 99556; HomoloGene: 20256; GeneCards: PDE4C; OMA:PDE4C - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 18,208,652 bp[1] End 18,248,200 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B3.3|8 34.15 cM Start 71,176,369 bp[2] End 71,203,835 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart muscle of thigh tibial arteries spleen skeletal muscle tissue gastrocnemius muscle left ventricle testicle muscle layer of sigmoid colon stromal cell of endometrium Top expressed in renal cortex proximal tubule human kidney right kidney islet of Langerhans hepatobiliary system liver muscle of thigh muscle tissue duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoric diester hydrolase activity protein binding 3',5'-cyclic-nucleotide phosphodiesterase activity hydrolase activity metal ion binding 3',5'-cyclic-AMP phosphodiesterase activity Cellular component cytosol cell projection extracellular space cilium Biological process cAMP catabolic process signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5143 110385 Ensembl ENSG00000105650 ENSMUSG00000031842 UniProt Q08493 Q3UEI1 RefSeq (mRNA) NM_000923 NM_001098818 NM_001098819 NM_001330172 NM_001369701 NM_001395274 NM_201607 NM_001310465 RefSeq (protein) NP_000914 NP_001092288 NP_001092289 NP_001317101 NP_001356630 NP_001297394 NP_963901 Location (UCSC) Chr 19: 18.21 – 18.25 Mb Chr 8: 71.18 – 71.2 Mb PubMed search [3] [4]
Wikidata
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Tissue localisation

PDE4C is predominantly found in peripheral tissues.^[6]