PDE4D

cAMP-specific 3',5'-cyclic phosphodiesterase 4D is an enzyme that in humans is encoded by the PDE4D gene.

PDE4D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MKD, 1OYN, 1PTW, 1Q9M, 1TB7, 1TBB, 1XOM, 1XON, 1XOQ, 1XOR, 1Y2B, 1Y2C, 1Y2D, 1Y2E, 1Y2K, 1ZKN, 2FM0, 2FM5, 2PW3, 2QYN, 3G4G, 3G4I, 3G4K, 3G4L, 3G58, 3IAD, 3IAK, 3K4S, 3SL3, 3SL4, 3SL5, 3SL6, 3SL8, 3V9B, 4OGB, 4W1O, 4WCU
Identifiers
Aliases	PDE4D, ACRDYS2, DPDE3, HSPDE43, PDE4DN2, STRK1, phosphodiesterase 4D
External IDs	OMIM: 600129; MGI: 99555; HomoloGene: 129755; GeneCards: PDE4D; OMA:PDE4D - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q11.2-q12.1 Start 58,969,038 bp[1] End 60,522,120 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 D2.1|13 59.69 cM Start 108,586,482 bp[2] End 110,089,995 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in glutes muscle of arm biceps brachii Skeletal muscle tissue of rectus abdominis triceps brachii muscle Skeletal muscle tissue of biceps brachii thoracic diaphragm Achilles tendon gastrocnemius muscle vastus lateralis muscle Top expressed in muscle of thigh skeletal muscle tissue quadriceps femoris muscle olfactory bulb Cortex of frontal lobe right kidney proximal tubule superior frontal gyrus primary visual cortex thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase binding scaffold protein binding cAMP binding metal ion binding beta-2 adrenergic receptor binding protein binding phosphoric diester hydrolase activity enzyme binding hydrolase activity ubiquitin protein ligase binding transmembrane transporter binding 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity Cellular component cytoplasm cytosol centrosome microtubule organizing center apical plasma membrane cytoskeleton membrane calcium channel complex voltage-gated calcium channel complex plasma membrane nuclear membrane Biological process establishment of endothelial barrier smooth muscle contraction positive regulation of interleukin-5 production multicellular organism growth ageing regulation of signaling receptor activity positive regulation of interferon-gamma production neutrophil chemotaxis positive regulation of interleukin-2 production regulation of cell communication by electrical coupling involved in cardiac conduction adrenergic receptor signaling pathway cellular response to lipopolysaccharide T cell receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate cAMP-mediated signaling cellular response to cAMP signal transduction leukocyte migration negative regulation of relaxation of cardiac muscle regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum negative regulation of heart contraction regulation of heart rate regulation of ryanodine-sensitive calcium-release channel activity cAMP catabolic process cellular response to epinephrine stimulus regulation of cardiac muscle cell contraction negative regulation of peptidyl-serine phosphorylation G protein-coupled receptor signaling pathway negative regulation of cAMP-mediated signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5144 238871 Ensembl ENSG00000113448 ENSMUSG00000021699 UniProt Q08499 Q01063 RefSeq (mRNA) NM_001104631 NM_001165899 NM_001197218 NM_001197219 NM_001197220 NM_001197221 NM_001197222 NM_001197223 NM_006203 NM_001349241 NM_001349242 NM_001349243 NM_001364599 NM_001364600 NM_001364601 NM_001364602 NM_001364603 NM_001364604 NM_011056 NM_177252 RefSeq (protein) NP_001098101 NP_001159371 NP_001184147 NP_001184148 NP_001184149 NP_001184150 NP_001184151 NP_001184152 NP_006194 NP_001336170 NP_001336171 NP_001336172 NP_001351528 NP_001351529 NP_001351530 NP_001351531 NP_001351532 NP_001351533 NP_035186 NP_001389812 NP_001389813 NP_001389814 NP_001389815 NP_001389816 NP_001389817 Location (UCSC) Chr 5: 58.97 – 60.52 Mb Chr 13: 108.59 – 110.09 Mb PubMed search [3] [4]
Wikidata
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Function

The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins. These proteins degrade the second messenger cAMP, which is a key signal transduction molecule in multiple cell types, including vascular cells (Dominiczak and McBride, 2003).[supplied by OMIM]^[5]

Interactions

PDE4D has been shown to interact with myomegalin^[6] and GNB2L1.^[7][8]

Clinical relevance

Mutations in this gene have been associated to cases of acrodysostosis.^[9]

This is the subtype of PDE4 that appears to be involved in the emetic and antidepressant effects of PDE4 inhibitors.^[10]

Furthermore, changes in expression of the isoform PDE4D7 have been proposed as prostate cancer biomarker. ^{[11] [12] [13]}