PDE6C

Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' is an enzyme that in humans is encoded by the PDE6C gene.^[5]

PDE6C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JWQ, 3JWR, 5E8F
Identifiers
Aliases	PDE6C, ACHM5, COD4, PDEA2, phosphodiesterase 6C
External IDs	OMIM: 600827; MGI: 105956; HomoloGene: 4521; GeneCards: PDE6C; OMA:PDE6C - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.33 Start 93,612,537 bp[1] End 93,666,010 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C2 Start 38,121,229 bp[2] End 38,172,406 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte testicle cerebellar hemisphere right hemisphere of cerebellum ectocervix tibial nerve right lung gastrocnemius muscle canal of the cervix body of uterus Top expressed in neural layer of retina pineal gland epithelium of lens yolk sac retinal pigment epithelium choroid plexus of fourth ventricle embryo liver primitive streak iris More reference expression data BioGPS n/a
Gene ontology Molecular function phosphoric diester hydrolase activity nucleotide binding cGMP binding 3',5'-cyclic-GMP phosphodiesterase activity hydrolase activity 3',5'-cyclic-nucleotide phosphodiesterase activity metal ion binding Cellular component plasma membrane membrane Biological process sensory perception of light stimulus retinal cone cell development signal transduction visual perception phototransduction, visible light response to stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5146 110855 Ensembl ENSG00000095464 ENSMUSG00000024992 UniProt P51160 Q91ZQ1 RefSeq (mRNA) NM_006204 NM_001170959 NM_033614 RefSeq (protein) NP_006195 NP_001164430 NP_291092 Location (UCSC) Chr 10: 93.61 – 93.67 Mb Chr 19: 38.12 – 38.17 Mb PubMed search [3] [4]
Wikidata
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