PDE6G

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma is an enzyme that in humans is encoded by the PDE6G gene.^[5][6][7]

PDE6G
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JWR
Identifiers
Aliases	PDE6G, PDEG, RP57, phosphodiesterase 6G
External IDs	OMIM: 180073; MGI: 97526; HomoloGene: 1955; GeneCards: PDE6G; OMA:PDE6G - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 81,650,459 bp[1] End 81,663,112 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E2|11 84.14 cM Start 120,338,431 bp[2] End 120,344,326 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad granulocyte lymph node spleen retinal pigment epithelium monocyte secondary oocyte blood bone marrow cells Top expressed in neural layer of retina epithelium of lens pineal gland retinal pigment epithelium corneal stroma gastrula iris outer nuclear layer right ventricle ciliary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme inhibitor activity spectrin binding cGMP binding protein binding 3',5'-cyclic-GMP phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity hydrolase activity Cellular component plasma membrane photoreceptor disc membrane photoreceptor outer segment membrane Biological process positive regulation of G protein-coupled receptor signaling pathway positive regulation of epidermal growth factor receptor signaling pathway visual perception response to stimulus regulation of rhodopsin mediated signaling pathway negative regulation of catalytic activity Wnt signaling pathway, calcium modulating pathway rhodopsin mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5148 18588 Ensembl ENSG00000185527 ENSMUSG00000025386 UniProt P18545 P09174 RefSeq (mRNA) NM_002602 NM_001365724 NM_001365725 NM_012065 RefSeq (protein) NP_002593 NP_001352653 NP_001352654 NP_036197 Location (UCSC) Chr 17: 81.65 – 81.66 Mb Chr 11: 120.34 – 120.34 Mb PubMed search [3] [4]
Wikidata
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Interactions

PDE6G has been shown to interact with Beta adrenergic receptor kinase^[8] and Src.^[8]