PDE8B

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B is an enzyme that in humans is encoded by the PDE8B gene.^[4][5]

PDE8B
Identifiers
Aliases	PDE8B, ADSD, PPNAD3, phosphodiesterase 8B
External IDs	OMIM: 603390; MGI: 2443999; HomoloGene: 2758; GeneCards: PDE8B; OMA:PDE8B - orthologs
Gene location (Mouse) Chr. Chromosome 13 (mouse)[1] Band 13|13 D1 Start 95,160,962 bp[1] End 95,386,844 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in olfactory tubercle superior frontal gyrus ventromedial nucleus pineal gland nucleus accumbens piriform cortex Region I of hippocampus proper posterior nasal aperture toe neural layer of retina BioGPS More reference expression data
Gene ontology Molecular function phosphoric diester hydrolase activity hydrolase activity 3',5'-cyclic-nucleotide phosphodiesterase activity metal ion binding 3',5'-cyclic-AMP phosphodiesterase activity Cellular component cytosol cellular component Biological process cyclic nucleotide metabolic process cAMP catabolic process signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8622 218461 Ensembl ENSG00000113231 ENSMUSG00000021684 UniProt O95263 E9Q4S1 RefSeq (mRNA) NM_001029851 NM_001029852 NM_001029853 NM_001029854 NM_003719 NM_001349748 NM_001349749 NM_001349750 NM_001349751 NM_001349752 NM_001349753 NM_001170669 NM_172263 NM_001346782 NM_001374003 NM_001374004 NM_001374005 NM_001374006 NM_001374007 RefSeq (protein) NP_001025022 NP_001025023 NP_001025024 NP_001025025 NP_003710 NP_001336677 NP_001336678 NP_001336679 NP_001336680 NP_001336681 NP_001336682 NP_001362991 NP_001362992 NP_001362993 NP_001362994 NP_001362995 NP_001362996 NP_001362997 NP_001362998 NP_001362999 NP_001363000 NP_001363001 NP_001363002 NP_001363003 NP_001363004 NP_001164140 NP_001333711 NP_758467 NP_001360932 NP_001360933 NP_001360934 NP_001360935 NP_001360936 NP_001391617 NP_001391618 NP_001391619 NP_001391620 NP_001391621 NP_001391622 NP_001391623 NP_001391624 NP_001391625 Location (UCSC) n/a Chr 13: 95.16 – 95.39 Mb PubMed search [2] [3]
Wikidata
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Clinical significance

PDE8B expression has been linked to higher survival rates for lung adenocarcinoma patients.^[6]