PDZD2

PDZ domain-containing protein 2 is a protein that in humans is encoded by the PDZD2 gene.^[5][6]

PDZD2
Identifiers
Aliases	PDZD2, AIPC, PAPIN, PDZK3, PIN1, PDZ domain containing 2
External IDs	OMIM: 610697; MGI: 1922394; HomoloGene: 23393; GeneCards: PDZD2; OMA:PDZD2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p13.3 Start 31,639,131 bp[1] End 32,110,932 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 A1 Start 12,359,797 bp[2] End 12,740,010 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trigeminal ganglion spinal ganglia skin of thigh postcentral gyrus external globus pallidus Epithelium of choroid plexus skin of hip buccal mucosa cell placenta sural nerve Top expressed in olfactory tubercle right lung right lung lobe left lung lobe primary oocyte zygote epithelium of small intestine skin of back skin of external ear ascending aorta More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 23037 68070 Ensembl ENSG00000133401 ENSMUSG00000022197 UniProt O15018 n/a RefSeq (mRNA) NM_015022 NM_178140 NM_001081064 RefSeq (protein) NP_835260 n/a Location (UCSC) Chr 5: 31.64 – 32.11 Mb Chr 15: 12.36 – 12.74 Mb PubMed search [3] [4]
Wikidata
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Function

Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling.^[ambiguous] The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.^[6]

Interactions

PDZD2 has been shown to interact with PKP4.^[7][8]