PEA15

Astrocytic phosphoprotein PEA-15 is a protein that in humans is encoded by the PEA15 gene.^[5][6]

PEA15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4IZ5, 4IZA, 1N3K,%%s1N3K
Identifiers
Aliases	PEA15, HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED, phosphoprotein enriched in astrocytes 15, PED-PED/proliferation and apoptosis adaptor protein 15
External IDs	OMIM: 603434; MGI: 104799; HomoloGene: 7884; GeneCards: PEA15; OMA:PEA15 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.2 Start 160,205,380 bp[1] End 160,215,376 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 79.54 cM Start 172,024,295 bp[2] End 172,034,371 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in dorsal motor nucleus of vagus nerve spinal cord C1 segment subthalamic nucleus inferior ganglion of vagus nerve internal globus pallidus superior vestibular nucleus external globus pallidus inferior olivary nucleus pars reticulata Top expressed in ventricular zone neural layer of retina dentate gyrus of hippocampal formation granule cell subiculum optic nerve cerebellar cortex arcuate nucleus ventromedial nucleus ventral tegmental area median eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm microtubule associated complex nucleus cytosol Biological process MAPK cascade negative regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of apoptotic process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of glucose import apoptotic process carbohydrate transport DNA damage checkpoint signaling response to morphine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8682 18611 Ensembl ENSG00000162734 ENSMUSG00000013698 UniProt Q15121 Q62048 RefSeq (mRNA) NM_001297576 NM_001297577 NM_001297578 NM_003768 NM_011063 NM_001329869 NM_001329871 NM_008556 RefSeq (protein) NP_001284505 NP_001284506 NP_001284507 NP_003759 NP_001284506.1 NP_003759.1 NP_001316798 NP_001316800 NP_035193 Location (UCSC) Chr 1: 160.21 – 160.22 Mb Chr 1: 172.02 – 172.03 Mb PubMed search [3] [4]
Wikidata
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PEA15 is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes.^[6]

PEA-15 promotes autophagy in glioma cells in a JNK-dependent manner.^[7]

Interactions

PEA15 has been shown to interact with:

• Caspase 8,^[8][9]
• FADD,^[8][9] and
• MAPK1,^[10]
• Phospholipase D1,^[11] and
• RPS6KA3.^[12]