PELI1

Protein pellino homolog 1 is a protein that in humans is encoded by the PELI1 gene.^[5][6][7]

PELI1
Identifiers
Aliases	PELI1, pellino E3 ubiquitin protein ligase 1
External IDs	OMIM: 614797; MGI: 1914495; HomoloGene: 23243; GeneCards: PELI1; OMA:PELI1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p14 Start 64,092,652 bp[1] End 64,144,420 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A3.1|11 13.81 cM Start 21,041,291 bp[2] End 21,100,323 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of paranasal sinus cartilage tissue mucosa of pharynx amniotic fluid skin of thigh vena cava oral cavity human penis bone marrow epithelium of nasopharynx Top expressed in medial ganglionic eminence blood mesenteric lymph nodes left lung lobe transitional epithelium of urinary bladder nucleus accumbens skin of external ear olfactory tubercle Rostral migratory stream anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-protein transferase activity protein binding ubiquitin-ubiquitin ligase activity protein serine/threonine kinase activity transferase activity ubiquitin protein ligase activity Cellular component cytosol nucleus Biological process response to dsRNA positive regulation of toll-like receptor 3 signaling pathway positive regulation of cytokine production protein polyubiquitination negative regulation of T cell proliferation response to lipopolysaccharide positive regulation of B cell proliferation protein ubiquitination positive regulation of toll-like receptor 4 signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of B cell activation negative regulation of NF-kappaB transcription factor activity positive regulation of protein ubiquitination negative regulation of T cell activation protein phosphorylation immune response Toll signaling pathway protein K48-linked ubiquitination interleukin-1-mediated signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of necroptotic process protein K63-linked ubiquitination regulation of Toll signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57162 67245 Ensembl ENSG00000197329 ENSMUSG00000020134 UniProt Q96FA3 Q8C669 RefSeq (mRNA) NM_020651 NM_023324 RefSeq (protein) NP_065702 NP_075813 Location (UCSC) Chr 2: 64.09 – 64.14 Mb Chr 11: 21.04 – 21.1 Mb PubMed search [3] [4]
Wikidata
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