PEX14

Peroxisomal membrane protein PEX14 is a protein that in humans is encoded by the PEX14 gene.^[5][6]

PEX14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2W84, 2W85, 4BXU
Identifiers
Aliases	PEX14, NAPP2, PBD13A, Pex14p, dJ734G22.2, peroxisomal biogenesis factor 14
External IDs	OMIM: 601791; MGI: 1927868; HomoloGene: 37936; GeneCards: PEX14; OMA:PEX14 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.22 Start 10,472,288 bp[1] End 10,630,758 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 149,044,992 bp[2] End 149,184,333 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell parotid gland right lobe of liver pancreatic ductal cell prefrontal cortex urinary bladder muscle of thigh olfactory zone of nasal mucosa endothelial cell oocyte Top expressed in otic placode saccule otic vesicle entorhinal cortex perirhinal cortex choroid plexus of fourth ventricle CA3 field Ileal epithelium lactiferous gland yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription corepressor activity protein N-terminus binding microtubule binding protein binding beta-tubulin binding signaling receptor binding Cellular component integral component of membrane membrane peroxisomal membrane peroxisome intracellular anatomical structure nucleus fibrillar center peroxisomal importomer complex protein-containing complex Biological process peroxisome organization negative regulation of protein homotetramerization peroxisome transport along microtubule negative regulation of protein binding negative regulation of DNA-binding transcription factor activity microtubule anchoring protein import into peroxisome matrix protein import into peroxisome matrix, substrate release protein transport negative regulation of transcription, DNA-templated protein homooligomerization protein import into peroxisome matrix, translocation transport protein targeting to peroxisome protein import into peroxisome matrix, docking protein ubiquitination protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5195 56273 Ensembl ENSG00000142655 ENSMUSG00000028975 UniProt O75381 Q9R0A0 RefSeq (mRNA) NM_004565 NM_019781 RefSeq (protein) NP_004556 NP_062755 Location (UCSC) Chr 1: 10.47 – 10.63 Mb Chr 4: 149.04 – 149.18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Peroxisomal membrane anchor protein (Pex14p) conserved region
Identifiers
Symbol	Pex14_N
Pfam	PF04695
InterPro	IPR006785
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Function

This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.^[6]

Interactions

PEX14 has been shown to interact with

• PEX5,^{[7][8][9][10]}
• PEX7,^[10] and
• PEX13.^[7]