PFDN2

Prefoldin subunit 2 is a protein that in humans is encoded by the PFDN2 gene.^[5][6]

PFDN2
Identifiers
Aliases	PFDN2, PFD2, prefoldin subunit 2
External IDs	OMIM: 613466; MGI: 1276111; HomoloGene: 7887; GeneCards: PFDN2; OMA:PFDN2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 161,100,556 bp[1] End 161,118,055 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 79.35 cM Start 171,173,238 bp[2] End 171,186,822 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment anterior cingulate cortex anterior pituitary ganglionic eminence Amygdala gastrocnemius muscle prefrontal cortex Brodmann area 9 Hypothalamus putamen Top expressed in lateral hypothalamus neural layer of retina paraventricular nucleus of hypothalamus central gray substance of midbrain medial vestibular nucleus ventromedial nucleus dorsomedial hypothalamic nucleus cingulate gyrus mammillary body supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function unfolded protein binding protein folding chaperone activity protein binding Cellular component cytoplasm mitochondrion nucleus prefoldin complex cytosol Biological process positive regulation of cytoskeleton organization protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5202 18637 Ensembl ENSG00000143256 ENSMUSG00000006412 UniProt Q9UHV9 O70591 RefSeq (mRNA) NM_012394 NM_011070 NM_001360824 NM_001360825 RefSeq (protein) NP_036526 NP_035200 NP_001347753 NP_001347754 Location (UCSC) Chr 1: 161.1 – 161.12 Mb Chr 1: 171.17 – 171.19 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.^[6]