PFDN4

Prefoldin subunit 4 is a protein that in humans is encoded by the PFDN4 gene.^[5][6][7]

PFDN4
Identifiers
Aliases	PFDN4, C1, PFD4, prefoldin subunit 4
External IDs	OMIM: 604898; MGI: 1923512; HomoloGene: 37645; GeneCards: PFDN4; OMA:PFDN4 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.2 Start 54,208,087 bp[1] End 54,228,052 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H3|2 91.91 cM Start 170,338,348 bp[2] End 170,361,043 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte ganglionic eminence Achilles tendon frontal pole Brodmann area 10 paraflocculus of cerebellum superficial temporal artery ventricular zone palpebral conjunctiva secondary oocyte Top expressed in zygote primary oocyte secondary oocyte medial ganglionic eminence hand epiblast facial motor nucleus ventricular zone embryo superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chaperone binding unfolded protein binding protein binding Cellular component cytosol nucleus cytoplasm prefoldin complex mitochondrion Biological process protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5203 109054 Ensembl ENSG00000101132 ENSMUSG00000052033 UniProt Q9NQP4 n/a RefSeq (mRNA) NM_002623 NM_001013369 NM_001110152 NM_001199902 RefSeq (protein) NP_002614 n/a Location (UCSC) Chr 20: 54.21 – 54.23 Mb Chr 2: 170.34 – 170.36 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.^[7]