PFDN5

Prefoldin subunit 5 is a protein that in humans is encoded by the PFDN5 gene.^[5][6][7]

PFDN5
Identifiers
Aliases	PFDN5, MM-1, MM1, PFD5, prefoldin subunit 5
External IDs	OMIM: 604899; MGI: 1928753; HomoloGene: 1972; GeneCards: PFDN5; OMA:PFDN5 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 53,295,291 bp[1] End 53,299,452 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F2|15 57.48 cM Start 102,234,551 bp[2] End 102,240,308 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary granulocyte left testis right testis canal of the cervix Hypothalamus nucleus accumbens Amygdala substantia nigra Top expressed in arcuate nucleus endocardial cushion mesenteric lymph nodes transitional epithelium of urinary bladder mammillary body paraventricular nucleus of hypothalamus globus pallidus lateral septal nucleus medial ganglionic eminence lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function unfolded protein binding protein binding transcription corepressor activity Cellular component cytoplasm nucleus prefoldin complex Biological process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated retina development in camera-type eye negative regulation of canonical Wnt signaling pathway protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5204 56612 Ensembl ENSG00000123349 ENSMUSG00000001289 UniProt Q99471 Q9WU28 RefSeq (mRNA) NM_145897 NM_002624 NM_145896 NM_020031 NM_027044 RefSeq (protein) NP_002615 NP_665904 NP_081320 Location (UCSC) Chr 12: 53.3 – 53.3 Mb Chr 15: 102.23 – 102.24 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described.^[7]

Interactions

PFDN5 has been shown to interact with Myc.^[6][8]